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Article

Increased Free Water in the Substantia Nigra in Asymptomatic LRRK2 G2019S Mutation Carriers.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2023

Zhang Dongling, Zhou Liche, Shi Yuting, Liu Jun, Wei Hongjiang, Tong Qiqi, He Hongjian, Wu Tao

Abstract excerpt

BACKGROUND: The alteration of substantia nigra (SN) degeneration in populations at risk of Parkinson's disease (PD) is unclear. OBJECTIVE: We investigated free water (FW) values in the posterior SN (pSN) in asymptomatic LRRK2 G2019S mutation carriers. METHODS: We analyzed diffusion imaging data from 28 asymptomatic LRRK2 G2019S mutation carriers and 30 healthy controls (HCs), whereas 11 asymptomatic LRRK2 G2019S...

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PMID: 36253640
DOI: 10.1002/mds.29253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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