Article
Increased basal forebrain volumes could prevent cognitive decline in LRRK2 Parkinson's disease.
Neurobiology of disease - 1 Jul 2023
Batzu Lucia, Urso Daniele, Grothe Michel J, Veréb Dániel, Chaudhuri K Ray, Pereira Joana B
Abstract excerpt
BACKGROUND AND OBJECTIVES: It has been recently suggested that LRRK2 mutations are associated with a more benign clinical phenotype and a potentially more preserved cholinergic function in Parkinson's disease (PD). However, to our knowledge, no studies have tested whether the better clinical progression observed in LRRK2-PD patients is associated with more preserved volumes of a cholinergic brain area, the basal...
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