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Gene therapy with the TRF 1 telomere gene rescues decreased TRF 1 levels with aging and prolongs mouse health span

24 Sept 2017

Abstract excerpt

The shelterin complex protects telomeres by preventing them from being degraded and recognized as double-strand DNA breaks. TRF1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. We previously showed that TRF1 deficiency in the context of different mouse tissues leads to loss of tissue homeostasis owing to impaired stem cell function. Here, we show that...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 28944611
DOI: 10.1111/acel.12677

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