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Article

Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.

PLoS pathogens - 1 Dec 2024

Bilev Eleni, Wild Nicole, Momayyezi Pouria, Sala Benedetta Maria, Sun Renhua, Sandalova Tatyana, Marquardt Nicole, Ljunggren Hans-Gustaf, Achour Adnane, Hammer Quirin

Abstract excerpt

In addition to adaptive immunity, natural killer (NK) cells of the innate immune system contribute to the control of viral infections. The HLA-E-restricted SARS-CoV-2 Nsp13232-240 epitope VMPLSAPTL renders infected cells susceptible to NK cells by preventing binding to the inhibitory receptor NKG2A. Here, we report that a recently emerged methionine to isoleucine substitution at position 2 (pM2I) of Nsp13232-240...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39652590
DOI: 10.1371/journal.ppat.1012755
PMCID: PMC11658698

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