SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses.

doi:10.1126/sciimmunol.abg6461

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Article

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses.

Science immunology - 4 Mar 2021

Agerer Benedikt, Koblischke Maximilian, Gudipati Venugopal, Montaño-Gutierrez Luis Fernando, Smyth Mark, Popa Alexandra, Genger Jakob-Wendelin, Endler Lukas, Florian David M, Mühlgrabner Vanessa, Graninger Marianne, Aberle Stephan W, Husa Anna-Maria, Shaw Lisa Ellen, Lercher Alexander, Gattinger Pia, Torralba-Gombau Ricard, Trapin Doris, Penz Thomas, Barreca Daniele, Fae Ingrid, Wenda Sabine, Traugott Marianna, Walder Gernot, Pickl Winfried F, Thiel Volker, Allerberger Franz, Stockinger Hannes, Puchhammer-Stöckl Elisabeth, Weninger Wolfgang, Fischer Gottfried, Hoepler Wolfgang, Pawelka Erich, Zoufaly Alexander, Valenta Rudolf, Bock Christoph, Paster Wolfgang, Geyeregger René, Farlik Matthias, Halbritter Florian, Huppa Johannes B, Aberle Judith H, Bergthaler Andreas

Abstract excerpt

CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding in a cell-free in vitro assay. Reduced MHC-I binding of mutant peptides was associated with decreased proliferation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33664060
DOI: 10.1126/sciimmunol.abg6461
PMCID: PMC8224398

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