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Article

Structural insights into immune escape at killer T cell epitope by SARS-CoV-2 Spike Y453F variants.

The Journal of biological chemistry - 1 Aug 2024

Deng Shasha, Xu Zhihao, Wang Meihua, Hu Jing, Liu Zhuan, Zhu Fang, Zheng Peiyi, Kombe Kombe Arnaud John, Zhang Hongliang, Wu Songquan, Jin Tengchuan

Abstract excerpt

CD8+ T cell immunity, mediated by human leukocyte antigen (HLA) and T cell receptor (TCR), plays a critical role in conferring immune memory and protection against viral pathogens. The emergence of SARS-CoV-2 variants poses a serious challenge to the efficacy of current vaccines. Whereas numerous SARS-CoV-2 mutations associated with immune escape from CD8+ T cells have been documented, the molecular effects of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epitopes, T-Lymphocyte

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Source

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Identifiers

PMID: 39002680
DOI: 10.1016/j.jbc.2024.107563
PMCID: PMC11342781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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