Article

Impacts of 203/204: RG>KR mutation in the N protein of SARS-CoV-2

2021-01-14

Abstract excerpt

We present a structure-based model of phosphorylation-dependent binding and sequestration of SARS-CoV-2 nucleocapsid protein and the impact of two consecutive amino acid changes R203K and G204R. Additionally, we studied how mutant strains affect HLA-specific antigen presentation and correlated these findings with HLA allelic population frequencies. We discovered RG>KR mutated SARS-CoV-2 expands the ability for dif...

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Literature Corpus work: 481ab19e-5750-522c-8d42-6275e5f6e432
DOI: 10.1101/2021.01.14.426726

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