Article
Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India.
BMC cancer - 22 Nov 2017
Ghosh Sudakshina, Bankura Biswabandhu, Ghosh Soumee, Saha Makhan Lal, Pattanayak Arup Kumar, Ghatak Souvik, Guha Manalee, Nachimuthu Senthil Kumar, Panda Chinmoy Kumar, Maji Suvendu, Chakraborty Subrata, Maity Biswanath, Das Madhusudan
Abstract excerpt
BACKGROUND: Gastric cancer (GC) is one of the most frequently diagnosed digestive tract cancers and carries a high risk of mortality. Acetaldehyde (AA), a carcinogenic intermediate of ethanol metabolism contributes to the risk of GC. The accumulation of AA largely depends on the activity of the major metabolic enzymes, alcohol dehydrogenase and aldehyde dehydrogenase encoded by the ADH (ADH1 gene cluster: ADH1A,...
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