Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer.

doi:10.1002/cam4.4920

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Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer.

Cancer medicine - 1 Jan 2023

Chang Ting-Gang, Yen Ting-Ting, Wei Chia-Yi, Hsiao Tzu-Hung, Chen I-Chieh

Abstract excerpt

BACKGROUND: ADH1B rs1229984 and ALDH2 rs671 are the specifically prevalent functional variants in the East Asians. These variants, which result in a dramatic change in enzyme activity, are highly associated with alcohol-related disorders and cancer. Previous studies focusing on the additive and synergic effects of the variants are few and inconsistent. The aim of the research was to evaluate the associations of...

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PMID: 35670037
DOI: 10.1002/cam4.4920
PMCID: PMC9844601

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