Article
ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population.
Oral oncology - 1 Jul 2011
Ji Yong Bae, Tae Kyung, Ahn Tae Hwan, Lee Seung Hwan, Kim Kyung Rae, Park Chul Won, Park Byung Lae, Shin Hyoung Doo
Abstract excerpt
Alcohol consumption is a major risk factor for squamous cell carcinoma of the head and neck (SCCHN). Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are key enzymes in ethanol metabolism. The objective of this study was to investigate the relationships of ADH and ALDH single nucleotide polymorphisms (SNPs) with the risk of developing SCCHN in a Korean sample. We genotyped ADH1B +3170A>G (rs1229984)...
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