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Article

Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.

Gastroenterology - 1 Nov 2009

Cui Ri, Kamatani Yoichiro, Takahashi Atsushi, Usami Masayuki, Hosono Naoya, Kawaguchi Takahisa, Tsunoda Tatsuhiko, Kamatani Naoyuki, Kubo Michiaki, Nakamura Yusuke, Matsuda Koichi

Abstract excerpt

BACKGROUND & AIMS: Esophageal squamous cell carcinoma (ESCC) is prevalent among Asian populations, with marked regional variations in incidence and mortality. Patients with ESCC have a very poor prognosis, but detection of ESCC at earlier stages could improve clinical outcome. Therefore, identification of epidemiologic factors that influence the development of ESCC would facilitate prevention and/or early...

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Share to Alcohol Dehydrogenase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Aldehyde Dehydrogenase, Mitochondrial

Share to Carcinoma, Squamous Cell

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Source

Identifiers

PMID: 19698717
DOI: 10.1053/j.gastro.2009.07.070

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.PMID 19698717Read ↗

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Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer RiskSemantic proximity Read ↗

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Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.Semantic proximity Read ↗

Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer.Semantic proximity Read ↗

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