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Identification of transcriptionally‐active human papillomavirus integrants through nanopore sequencing reveals viable targets for gene therapy against cervical cancer

1 Jun 2024

Abstract excerpt

Integration of the human papillomavirus (HPV) genome into the cellular genome is a key event that leads to constitutive expression of viral oncoprotein E6/E7 and drives the progression of cervical cancer. However, HPV integration patterns differ on a case-by-case basis among related malignancies. Next-generation sequencing technologies still face challenges for interrogating HPV integration sites. In this study,...

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PMID: 38932482
DOI: 10.1002/jmv.29769

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