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Article

Pathogenesis and management of high molecular risk myeloproliferative neoplasms.

Haematologica - 1 Apr 2025

Ling Victoria Y, Heidel Florian H, Bywater Megan J

Abstract excerpt

Classical myeloproliferative neoplasms (MPN) are clonal stem cell disorders characterized by driver mutations that affect the constitutive activation of JAK-signaling. Mutations additional to an MPN-driver occur in a large number of patients and have been shown be associated with disease presentation and progression. In this review, we outline the current hypotheses regarding how clonal evolution in MPN is...

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Identifiers

PMID: 39633552
DOI: 10.3324/haematol.2023.283987
PMCID: PMC11959265

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