Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Pathogenesis and management of high molecular risk myeloproliferative neoplasms.

Haematologica - 1 Apr 2025

Ling Victoria Y, Heidel Florian H, Bywater Megan J

Abstract excerpt

Classical myeloproliferative neoplasms (MPN) are clonal stem cell disorders characterized by driver mutations that affect the constitutive activation of JAK-signaling. Mutations additional to an MPN-driver occur in a large number of patients and have been shown be associated with disease presentation and progression. In this review, we outline the current hypotheses regarding how clonal evolution in MPN is...

Topics

Humans
Myeloproliferative Disorders
Mutation
Disease Management
Clonal Evolution
Genetic Predisposition to Disease
Signal Transduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39633552
DOI: 10.3324/haematol.2023.283987
PMCID: PMC11959265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathogenesis and management of high molecular risk myeloproliferative neoplasmsPMID 39633552Read ↗

Molecular Pathogenesis of Myeloproliferative Neoplasms.Semantic proximity Read ↗

Myeloproliferative Neoplasms: Molecular Drivers and Therapeutics.Semantic proximity Read ↗

Molecular Pathogenesis of Myeloproliferative Neoplasms: From Molecular Landscape to Therapeutic Implications.Semantic proximity Read ↗

Biology and Current Treatment of Myeloproliferative Neoplasms.Semantic proximity Read ↗

Molecular diagnostic criteria of myeloproliferative neoplasms.Semantic proximity Read ↗

Genetic basis and molecular profiling in myeloproliferative neoplasms.Semantic proximity Read ↗

Recent insights regarding the molecular basis of myeloproliferative neoplasms.Semantic proximity Read ↗

Integration of Molecular Information in Risk Assessment of Patients with Myeloproliferative Neoplasms.Semantic proximity Read ↗

Molecular pathogenesis of the myeloproliferative neoplasms.Semantic proximity Read ↗

Myeloproliferative neoplasms: updates on molecular pathophysiology, diagnosis and treatment strategies.Semantic proximity Read ↗

Molecular basis and clonal evolution of myeloproliferative neoplasms.Semantic proximity Read ↗

Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.