Article
CD4 T cells: fates, functions, and faults.
Blood - 1 Sept 2008
Zhu Jinfang, Paul William E
Abstract excerpt
In 1986, Mosmann and Coffman identified 2 subsets of activated CD4 T cells, Th1 and Th2 cells, which differed from each other in their pattern of cytokine production and their functions. Our understanding of the importance of the distinct differentiated forms of CD4 T cells and of the mechanisms through which they achieve their differentiated state has greatly expanded over the past 2 decades. Today at least 4...
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