Article
A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort.
Genomics - 1 Jul 2021
Müller Stephanie J, Schurz Haiko, Tromp Gerard, van der Spuy Gian D, Hoal Eileen G, van Helden Paul D, Owusu-Dabo Ellis, Meyer Christian G, Muntau Birgit, Thye Thorsten, Niemann Stefan, Warren Robin M, Streicher Elizabeth, Möller Marlo, Kinnear Craig
Abstract excerpt
Despite decades of research and advancements in diagnostics and treatment, tuberculosis remains a major public health concern. New computational methods are needed to interrogate the intersection of host- and bacterial genomes. Paired host genotype datum and infecting bacterial isolate information were analysed for associations using a multinomial logistic regression framework implemented in SNPTest. A cohort of...
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