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Article

Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2009

Guo Xiaochuan, Hamilton Peter J, Reish Nicholas J, Sweatt J David, Miller Courtney A, Rumbaugh Gavin

Abstract excerpt

Abnormal function of NMDA receptors is believed to be a contributing factor to the pathophysiology of schizophrenia. NMDAR subunits and postsynaptic-interacting proteins of these channels are abnormally expressed in some patients with this illness. In mice, reduced NMDAR expression leads to behaviors analogous to symptoms of schizophrenia, but reports of animals with mutations in core postsynaptic density...

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Identifiers

PMID: 19145222
DOI: 10.1038/npp.2008.223
PMCID: PMC3690772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia.PMID 19145222Read ↗

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