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Article

Cancer-associated fibroblast classification in single-cell and spatial proteomics data.

Nature communications - 18 Jul 2023

Cords Lena, Tietscher Sandra, Anzeneder Tobias, Langwieder Claus, Rees Martin, de Souza Natalie, Bodenmiller Bernd

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are a diverse cell population within the tumour microenvironment, where they have critical effects on tumour evolution and patient prognosis. To define CAF phenotypes, we analyse a single-cell RNA sequencing (scRNA-seq) dataset of over 16,000 stromal cells from tumours of 14 breast cancer patients, based on which we define and functionally annotate nine CAF phenotypes and one...

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Identifiers

PMID: 37463917
DOI: 10.1038/s41467-023-39762-1
PMCID: PMC10354071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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