Article

Unraveling the role of CLOCK gene in fibrotic skin diseases: insights from single-cell RNA sequencing analysis

2025-04-10

Abstract excerpt

<title>Abstract</title> <p>Fibrosis, characterized by excessive extracellular matrix (ECM) accumulation and fibroblast proliferation, significantly contributes to global morbidity and mortality, affecting millions worldwide. Despite its prevalence, the mechanisms underlying fibrotic skin diseases remain poorly understood, and effective treatments are scarce. This study leverages single-cell RNA sequencing (scRNA-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 462676e3-d586-58ba-a5cb-3783c4c24f7c
DOI: 10.21203/rs.3.rs-6196592/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unraveling the role of CLOCK gene in fibrotic skin diseases: insights from single-cell RNA sequencing analysisDOI 10.21203/rs.3.rs-6196592/v1Read

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseasesSemantic proximity Read

Skin fibroblast functional heterogeneity in health and diseaseSemantic proximity Read

Decoding the molecular landscape of keloids: new insights from single-cell transcriptomicsSemantic proximity Read

A consensus single-cell transcriptomic atlas of dermal fibroblast heterogeneitySemantic proximity Read

Machine learning and single‐cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P‐Smad 2/3 signalling pathway in hypertrophic scarSemantic proximity Read

New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell eraSemantic proximity Read

Unveiling COL4A1 as a Key Driver Gene in scleroderma: Insights from Single-Cell and Bulk RNA SequencingSemantic proximity Read

Single-cell RNA sequencing clarifies dermal fibroblast subset representation <i>in vitro</i> and reveals variable persistence of keloid disease-associated featuresSemantic proximity Read

Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanomaSemantic proximity Read

The Use of Single-Cell RNA-Sequencing and Spatial Transcriptomics in Understanding the Pathogenesis and Treatment of Skin DiseasesSemantic proximity Read

Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularisSemantic proximity Read

A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspectiveSemantic proximity Read