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Article

HLA-DRB10402 (DW10) transgene protects collagen-induced arthritis-susceptible H2Aq and DRB10401 (DW4) transgenic mice from arthritis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2003

Taneja Veena, Taneja Neelam, Behrens Marshall, Pan Suchong, Trejo Tad, Griffiths Marie, Luthra Harvinder, David Chella S

Abstract excerpt

To investigate the role of HLA-DR4 in predisposition to arthritis, we generated transgenic mice carrying DRB1*0401 and DRB1*0402 genes. We have previously shown that DRB1*0401 molecule renders B10.RQB3 (H2A(q)) mice susceptible to porcine and human type II collagen-induced arthritis. We report that the introduction of DRB1*0402 transgene does not lead to development of arthritis in mice when they are immunized...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14530370
DOI: 10.4049/jimmunol.171.8.4431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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