Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cross-restriction of a T cell clone to HLA-DR alleles associated with rheumatoid arthritis: clues to arthritogenic peptide motifs.

Arthritis and rheumatism - 1 May 1999

Hawke S, Matsuo H, Nicolle M, Wordsworth P, Corlett L, Spack E, Deshpande S, Driscoll P C, Willcox N

Abstract excerpt

OBJECTIVE: To identify distinctive sequence motifs required for productive peptide presentation by those HLA-DR alleles/DR4 subtypes that predispose to rheumatoid arthritis (RA). METHODS: We tested 10 different HLA-DR4 subtypes for presentation of acetylcholine receptor peptides to 8 different DR4-restricted T cell lines/clones in proliferation assays. RESULTS: Seven of the 8 T cells depended absolutely on either...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Presenting Cells
Share to Arginine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Clone Cells

Share to Cross Reactions

Share to Glycine

Share to Lysine

Share to Tryptophan

Source

Identifiers

PMID: 10323462
DOI: 10.1002/1529-0131(199905)42:5<1040::AID-ANR25>3.0.CO;2-X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-restriction of a T cell clone to HLA-DR alleles associated with rheumatoid arthritis: clues to arthritogenic peptide motifs.PMID 10323462Read ↗

Distant interactions between dimorphisms in HLA-DR4 radically affect recognition of defined peptides by a specific T cell clone.Semantic proximity Read ↗

Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.Semantic proximity Read ↗

T cell selection and differential activation on structurally related HLA-DR4 ligands.Semantic proximity Read ↗

Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis.Semantic proximity Read ↗

Major differences in antigen-processing correlate with a single Arg71<-->Lys substitution in HLA-DR molecules predisposing to rheumatoid arthritis and with their selective interactions with 70-kDa heat shock protein chaperones.Semantic proximity Read ↗

Association of MHC and rheumatoid arthritis. Association of RA with HLA-DR4: the role of repertoire selection.Semantic proximity Read ↗

Association of the HLA-DRB1 epitope LA(67, 74) with rheumatoid arthritis and citrullinated vimentin binding.Semantic proximity Read ↗

Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.Semantic proximity Read ↗

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.Semantic proximity Read ↗

Specific overexpression of rheumatoid arthritis-associated HLA-DR alleles and presentation of low-affinity peptides.Semantic proximity Read ↗

Disease-associated human histocompatibility leukocyte antigen determinants in patients with seropositive rheumatoid arthritis. Functional role in antigen-specific and allogeneic T cell recognition.Semantic proximity Read ↗

Scanning a DRB3*0101 (DR52a)-restricted epitope cross-presented by DR3: overlapping natural and artificial determinants in the human acetylcholine receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.