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Article

Breaking T cell tolerance against self type II collagen in HLA-DR4-transgenic mice and development of autoimmune arthritis.

Arthritis and rheumatism - 1 Jul 2010

Batsalova Tsvetelina, Dzhambazov Balik, Merky Patrick, Bäcklund Alexandra, Bäcklund Johan

Abstract excerpt

OBJECTIVE: To establish a new animal model in DRB1*0401 (DR4)-transgenic mice in which T cell tolerance to self type II collagen (CII) can be broken and allow for the development of autoimmune arthritis, to investigate the role of posttranslational modifications of the CII(259-273) epitope in the induction and breaking of tolerance of DR4-restricted T cells, and to characterize DR4-restricted T cell recognition...

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Identifiers

PMID: 20309862
DOI: 10.1002/art.27460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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