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Article

Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms

17 Feb 2014

Abstract excerpt

Autoantibody formation is essential for the development of certain autoimmune diseases like rheumatoid arthritis (RA). Anti-type II collagen (CII) antibodies are found in RA patients; they interact with cartilage in vivo and are often highly pathogenic in the mouse. Autoreactivity to CII is directed to multiple epitopes and conserved between mice and humans. We have previously mapped the antibody response to CII...

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PMID: 24534192
DOI: 10.1084/jem.20130968

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