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Article

Comprehensive Assessment of Initial Adaptation of Extended-Spectrum β-Lactamase-Positive ST131 Escherichia coli to Carbapenem Exposure.

The Journal of infectious diseases - 15 Apr 2025

Shropshire William C, Song Xinhao, Bremer Jordan, Seo Seokju, Rodriguez Susana, Selvaraj Anand Selvalakshmi, Dinh An Q, Bhatti Micah M, Konovalova Anna, Arias Cesar A, Kalia Awdhesh, Shamoo Yousif, Shelburne Samuel A

Abstract excerpt

BACKGROUND: It remains unclear how high-risk Escherichia coli lineages, like sequence type (ST) 131, initially adapt to carbapenem exposure in their progression to carbapenem resistance. METHODS: Carbapenem mutation frequency was measured in multiple subclades of extended-spectrum β-lactamase (ESBL)-positive ST131 clinical isolates using a fluctuation assay followed by whole genome sequencing (WGS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39602497
DOI: 10.1093/infdis/jiae587
PMCID: PMC11998557

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C2

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