Article
The epidemic of extended-spectrum-β-lactamase-producing Escherichia coli ST131 is driven by a single highly pathogenic subclone, H30-Rx.
mBio - 17 Dec 2013
Price Lance B, Johnson James R, Aziz Maliha, Clabots Connie, Johnston Brian, Tchesnokova Veronika, Nordstrom Lora, Billig Maria, Chattopadhyay Sujay, Stegger Marc, Andersen Paal S, Pearson Talima, Riddell Kim, Rogers Peggy, Scholes Delia, Kahl Barbara, Keim Paul, Sokurenko Evgeni V
Abstract excerpt
UNLABELLED: The Escherichia coli sequence type 131 (ST131) clone is notorious for extraintestinal infections, fluoroquinolone resistance, and extended-spectrum beta-lactamase (ESBL) production, attributable to a CTX-M-15-encoding mobile element. Here, we applied pulsed-field gel electrophoresis (PFGE) and whole-genome sequencing to reconstruct the evolutionary history of the ST131 clone. PFGE-based cluster...
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