An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL).

doi:10.1007/s00277-018-3297-6

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Article

An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL).

Annals of hematology - 1 Jun 2018

Khan Maliha, Siddiqi Rabbia, Naqvi Kiran

Abstract excerpt

Mixed phenotype acute leukemia (MPAL) is an uncommon diagnosis, representing only about 2-5% of acute leukemia cases. The blast cells of MPAL express multilineage immunophenotypic markers and may have a shared B/T/myeloid phenotype. Due to historical ambiguity in the diagnosis of MPAL, the genetics and clinical features of this disease remain poorly characterized. Based on the 2008 and 2016 World Health...

Topics

Combined Modality Therapy
Consolidation Chemotherapy
Evidence-Based Medicine
Gene Rearrangement
Hematopoietic Stem Cell Transplantation
Humans
Incidence
Leukemia, Biphenotypic, Acute
Mutation
Practice Guidelines as Topic
Prognosis
Translocation, Genetic
World Health Organization

Source

Open in PubMed

Identifiers

PMID: 29546454
DOI: 10.1007/s00277-018-3297-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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