Article
Acute Leukemias of Ambiguous Lineage With RUNX1 Mutations Show Similar Prognosis Compared to Acute Myeloid Leukemia With RUNX1 Mutations: A Study From the Bone Marrow Pathology Group.
American journal of hematology - 1 Jan 2026
Kirtek Timothy J, Chen Weina, Harris Jaryse C, Bagg Adam, Foucar Kathryn, Tam Wayne, Orazi Attilio, Hsi Eric D, Hasserjian Robert P, Wang Sa A, Ng David P, George Tracy I, Shi Min, Reichard Kaaren K, Symes Emily, Zhang Xinmin, Arber Daniel A, Weinberg Olga K
Abstract excerpt
The World Health Organization (WHO) 5th Edition and International Consensus Classification (ICC) have continued to delineate more genetically defined acute leukemias. Both recognize genetic aberrations associated with myelodysplastic syndromes/neoplasms (MDS) as defining MDS-related AML (AML-MR). Mutations in RUNX1 are included in this category in the ICC, but not WHO. The current classifications are unclear on...
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