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Article

Detection and Interpretation of Clonal Hematopoiesis Variants during Routine Solid Tumor Next-Generation Sequencing: A Single-Institution Experience.

The Journal of molecular diagnostics : JMD - 1 Dec 2024

Menon Adil, Sukhanova Madina, Nocito Kevin L, Gao Juehua, Jennings Lawrence J, Vormittag-Nocito Erica R

Abstract excerpt

Clonal hematopoiesis (CH) and clonal cytopenia of undetermined significance (CCUS) are recently recognized diagnostic entities that serve as independent risk factors for cardiovascular disease and myeloid malignancy. CH is an incidental finding, and evaluation of the incidence of CH/CCUS-associated mutations in solid tumor next-generation sequencing samples was undertaken to better understand the prevalence of...

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PMID: 39362468
DOI: 10.1016/j.jmoldx.2024.09.004

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