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Article

High-risk and silent clonal hematopoietic genotypes in patients with nonhematologic cancer.

Blood advances - 27 Feb 2024

Stonestrom Aaron J, Menghrajani Kamal N, Devlin Sean M, Franch-Expósito Sebastià, Ptashkin Ryan N, Patel Swara Y, Spitzer Barbara, Wu Xiaodi, Jee Justin, Sánchez Vela Pablo, Milbank Jennifer H, Shah Ronak H, Mohanty Abhinita S, Brannon A Rose, Xiao Wenbin, Berger Michael F, Mantha Simon, Levine Ross L

Abstract excerpt

ABSTRACT: Clonal hematopoiesis (CH) identified by somatic gene variants with variant allele fraction (VAF) ≥ 2% is associated with an increased risk of hematologic malignancy. However, CH defined by a broader set of genotypes and lower VAFs is ubiquitous in older individuals. To improve our understanding of the relationship between CH genotype and risk of hematologic malignancy, we analyzed data from 42 714...

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Source

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Identifiers

PMID: 38147626
DOI: 10.1182/bloodadvances.2023011262
PMCID: PMC10875331

Genes

JAK2
DNMT3A
RUNX1
TP53
XPO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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