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Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer

20 Nov 2024

Abstract excerpt

BACKGROUND: Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment and play a critical role in cancer progression. Numerous studies have identified significant molecular differences between CAFs and normal tissue-associated fibroblasts (NAFs). In this study, we isolated CAFs and NAFs from liver tumors and conducted a comprehensive analysis of their DNA methylation profiles,...

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PMID: 39567960
DOI: 10.1186/s13148-024-01783-y

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