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Methylome sequencing for fibrolamellar hepatocellular carcinoma depicts distinctive features

29 Jul 2015

Abstract excerpt

With the goal of studying epigenetic alterations in fibrolamellar hepatocellular carcinoma (FLC) and establish an associated DNA methylation signature, we analyzed LINE-1 methylation in a cohort of FLC and performed next-generation sequencing of DNA methylation in a training set of pure-FLCs and non-cirrhotic hepatocellular carcinomas (nc-HCC). DNA methylation was correlated with gene expression. Furthermore, we...

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PMID: 26224146
DOI: 10.1080/15592294.2015.1076955

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