Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes

20 Nov 2024

Abstract excerpt

Patients with type 2 and type 1 diabetes (T2D and T1D) exhibit sex-specific differences in insulin secretion, the mechanisms of which are unknown. We examined sex differences in human pancreatic islets from 52 donors with and without T2D combining single cell RNA-sequencing (scRNA-seq) and single nucleus ATAC-sequencing (snATAC-seq) with assays probing hormone secretion and bioenergetics. In non-diabetic (ND)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Pancreatic function and diabetes
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39567827
DOI: 10.1038/s44318-024-00313-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetesPMID 39567827Read ↗

Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.Semantic proximity Read ↗

Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.Semantic proximity Read ↗

Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetesSemantic proximity Read ↗

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes riskSemantic proximity Read ↗

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specificSemantic proximity Read ↗

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetesSemantic proximity Read ↗

Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes riskSemantic proximity Read ↗

Single-cell decoding of human islet cell type-specific alterations in type 2 diabetes reveals converging genetic- and state-driven β-cell gene expression defectsSemantic proximity Read ↗

Single cell ATAC-seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signaturesSemantic proximity Read ↗

Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures.Semantic proximity Read ↗

Sex differences in islet stress responses support female beta cell resilienceSemantic proximity Read ↗

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 DiabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.