Article

Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetes

2025-11-11

Abstract excerpt

The clinical characteristics of type 2 diabetes (T2D) differ between the sexes. For example, the risk of T2D is higher in males than in premenopausal females, whereas the risk of T2D-associated cardiovascular disease is higher in females. However, the sex-dependent mechanisms of T2D pathogenesis remain incompletely understood. Publicly available human islet datasets, such as HPAP and Humanislets.com , offer a val...

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Literature Corpus work: 34b0ff3e-26e4-54ef-9b78-351625470ef2
DOI: 10.1101/2025.11.10.687716

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