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Article

The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae.

The Journal of biological chemistry - 12 Jul 1996

Fang H, Panzner S, Mullins C, Hartmann E, Green N

Abstract excerpt

The multisubunit signal peptidase catalyzes the cleavage of signal peptides and the degradation of some membrane proteins within the endoplasmic reticulum (ER). The only subunit of this enzyme functionally examined to date, yeast Sec11p, is related to signal peptidase I from bacteria. Since bacterial signal peptidase is capable of processing both prokaryotic and eukaryotic signal sequences as a monomer, it is...

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PMID: 8663399
DOI: 10.1074/jbc.271.28.16460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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