Article
A single amino acid substitution alters ClpS2 binding specificity.
Proteins - 1 Sept 2020
Bergonzo Christina, Dharmadhikari Kunal, Samuels Emily, Christensen Makenzie, Tullman Jennifer
Abstract excerpt
ClpS2 is a small protein under development as a probe for selectively recognizing N-terminal amino acids of N-degron peptide fragments. To understand the structural basis of ClpS2 specificity for an N-terminal amino acid, all atom molecular dynamics (MD) simulations were conducted using the sequence of a bench-stable mutant of ClpS2, called PROSS. We predicted that a single amino acid leucine to asparagine...
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