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Article

Exocytosis requires asymmetry in the central layer of the SNARE complex.

The EMBO journal - 15 Nov 2000

Ossig R, Schmitt H D, de Groot B, Riedel D, Keränen S, Ronne H, Grubmüller H, Jahn R

Abstract excerpt

Assembly of SNAREs (soluble N:-ethylmaleimide- sensitive factor attachment protein receptors) mediates membrane fusions in all eukaryotic cells. The synaptic SNARE complex is represented by a twisted bundle of four alpha-helices. Leucine zipper-like layers extend through the length of the complex except for an asymmetric and ionic middle layer formed by three glutamines (Q) and one arginine (R). We have examined...

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Identifiers

PMID: 11080147
DOI: 10.1093/emboj/19.22.6000
PMCID: PMC305815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Exocytosis requires asymmetry in the central layer of the SNARE complex.PMID 11080147Read ↗

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