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Article

Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients.

European journal of clinical pharmacology - 1 Oct 2012

Chu Xiao-Man, Zhang Li-Fang, Wang Guang-Ji, Zhang Shen-Ning, Zhou Jia-Hui, Hao Hai-Ping

Abstract excerpt

PURPOSE: The aim of this study was to investigate the genetic polymorphisms of UGT1A3, UGT1A6, and UGT2B7 in Chinese epilepsy patients and their potential influence on the pharmacokinetics of valproic acid (VPA). METHODS: The genetic architectures of UGT1A3, UGT1A6, and UGT2B7 in 242 epilepsy patients were detected by DNA sequencing and PCR-restriction fragment length polymorphism. Steady-state plasma...

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Source

Identifiers

PMID: 22476391
DOI: 10.1007/s00228-012-1277-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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