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Associations of CYP2C9 and CYP2A6 Polymorphisms with the Concentrations of Valproate and its Hepatotoxin Metabolites and Valproate-Induced Hepatotoxicity.

Basic & clinical pharmacology & toxicology - 1 Aug 2017

Zhao Mingming, Zhang Ti, Li Guofei, Qiu Feng, Sun Yaxin, Zhao Limei

Abstract excerpt

The aim of this study was to compare genetic polymorphisms and concentrations of hepatotoxic metabolites in patients with epilepsy and liver injury and those with normal liver function receiving valproate monotherapy to identify risk factors for VPA-induced hepatotoxicity. A total of 279 Chinese patients with epilepsy were divided into an abnormal liver function (ANLFT) group (n = 79) and a normal liver function...

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PMID: 28273397
DOI: 10.1111/bcpt.12776

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