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Article

The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins.

EMBO reports - 1 Apr 2004

Klymenko Tetyana, Müller Jürg

Abstract excerpt

Transcriptional on and off states of HOX genes and other developmental control genes are maintained by antagonistic regulators encoded by trithorax group (trxG) and Polycomb group (PcG) genes. The trxG proteins Ash1 and hTRX and the PcG repressor E(z) are histone methyltransferases (HMTases) that methylate distinct lysine residues in the N-terminal tail of histone H3. trxG proteins are generally thought to...

Topics

Animals
Drosophila
Drosophila Proteins
Gene Silencing
Histone Methyltransferases
Histone-Lysine N-Methyltransferase
Homeodomain Proteins
Mutation
Polycomb Repressive Complex 1
Protein Methyltransferases

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Identifiers

PMID: 15031712
DOI: 10.1038/sj.embor.7400111
PMCID: PMC1299022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15031712-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins.PMID 15031712Read ↗

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