Article

A Regression-based Framework for Scalable Pathway-guided Search in Genome-wide Association Studies

2017-12-30

Abstract excerpt

Traditional unbiased genome-wide association studies (GWAS) have successfully identified thousands of loci associated with various complex diseases but there is evidence to suggest that many variants were missed at stringent genome-wide thresholds. Fortunately, there is a rapidly increasing amount of prior knowledge in publicly available genomic datasets and biological databases that can be harnessed to enhance th...

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Literature Corpus work: 9970296a-7e5c-5d12-92fa-b08b32faa8df
DOI: 10.1101/241265

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