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Article

Packing density of the erythropoietin receptor transmembrane domain correlates with amplification of biological responses.

Biochemistry - 11 Nov 2008

Becker Verena, Sengupta Durba, Ketteler Robin, Ullmann G Matthias, Smith Jeremy C, Klingmüller Ursula

Abstract excerpt

The formation of signal-promoting dimeric or oligomeric receptor complexes at the cell surface is modulated by self-interaction of their transmembrane (TM) domains. To address the importance of TM domain packing density for receptor functionality, we examined a set of asparagine mutants in the TM domain of the erythropoietin receptor (EpoR). We identified EpoR-T242N as a receptor variant that is present at the...

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PMID: 18855427
DOI: 10.1021/bi801425e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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