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Article

Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding.

Thrombosis and haemostasis - 1 Feb 2015

Du Jiangfeng, Wichapong Kanin, Hackeng Kanin M, Nicolaes Gerry A F

Abstract excerpt

The C-terminal C domains of activated coagulation factor VIII (FVIIIa) are essential to membrane binding of this crucial coagulation cofactor protein. To provide an overall membrane binding mechanism for FVIII, we performed simulations of membrane binding through coarse-grained molecular dynamics simulations of the C1 and C2 domain, and the combined C-domains (C1+C2). We found that the C1 and C2 domain have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25354705
DOI: 10.1160/TH14-02-0180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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