Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts.

doi:10.1186/s12964-024-01918-x

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Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts.

Cell communication and signaling : CCS - 14 Nov 2024

Gelsomino Luca, Caruso Amanda, Tasan Emine, Leonetti Adele Elisabetta, Malivindi Rocco, Naimo Giuseppina Daniela, Giordano Francesca, Panza Salvatore, Gu Guowei, Perrone Benedetta, Giordano Cinzia, Mauro Loredana, Nardo Bruno, Filippelli Gianfranco, Bonofiglio Daniela, Barone Ines, Fuqua Suzanne A W, Catalano Stefania, Andò Sebastiano

Abstract excerpt

BACKGROUND: Endocrine therapy (ET) has improved the clinical outcomes of Estrogen receptor alpha-positive (ERɑ +) breast cancer (BC) patients, even though resistance to ET remains a clinical issue. Mutations in the hormone-binding domain of ERɑ represent an acquired intrinsic mechanism of ET resistance. However, the latter also depends on the multiple functional interactions between BC cells and the tumor...

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PMID: 39543704
DOI: 10.1186/s12964-024-01918-x
PMCID: PMC11566413

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