Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hierarchical paracrine interaction of breast cancer associated fibroblasts with cancer cells via hMAPK-microRNAs to drive ER-negative breast cancer phenotype.

Cancer biology & therapy - 1 Jan 2015

Shah Sanket H, Miller Philip, Garcia-Contreras Marta, Ao Zheng, Machlin Leah, Issa Emilio, El-Ashry Dorraya

Abstract excerpt

Multiple juxtacrine and paracrine interactions occur between cancer cells and non-cancer cells of the tumor microenvironment (TME) that direct tumor progression. Cancer Associated Fibroblasts (CAFs) are an integral component of the TME, and the majority of breast tumor stroma is comprised of CAFs. Heterotypic interactions between cancer cells and non-cancer cells of the TME occur via soluble agents, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culture Media, Conditioned
Share to Exosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MCF-7 Cells

Share to Mitogen-Activated Protein Kinases

Share to Paracrine Communication

Share to Receptors, Estrogen

Share to RNA Interference

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 26186233
DOI: 10.1080/15384047.2015.1071742
PMCID: PMC4846097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hierarchical paracrine interaction of breast cancer associated fibroblasts with cancer cells via hMAPK-microRNAs to drive ER-negative breast cancer phenotype.PMID 26186233Read ↗

Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independenceSemantic proximity Read ↗

Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer ProgressionSemantic proximity Read ↗

The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like CarcinomasSemantic proximity Read ↗

Integrating spatial and single-cell transcriptomes reveals the role of COL1A2(+) MMP1(+/-) cancer-associated fibroblasts in ER-positive breast cancerSemantic proximity Read ↗

Cancer Associated Fibroblasts: The Architects of Stroma RemodelingSemantic proximity Read ↗

Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer.Semantic proximity Read ↗

At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable TargetsSemantic proximity Read ↗

Migratory Tumor Cells Cooperate with Cancer Associated Fibroblasts in Hormone Receptor-Positive and HER2-Negative Breast CancerSemantic proximity Read ↗

Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues.Semantic proximity Read ↗

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistanceSemantic proximity Read ↗

Dynamic interactions in the tumor niche: how the cross-talk between CAFs and the tumor microenvironment impacts resistance to therapySemantic proximity Read ↗

Plasticity and Functional Heterogeneity of Cancer-Associated FibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.