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Article

Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer.

Biology direct - 14 Nov 2024

Fang Yangyang, Fu Tianmei, Zhang Qian, Xiong Ziqing, Yu Kuai, Le Aiping

Abstract excerpt

BACKGROUND: Tumor Mutational Burden (TMB) have emerged as pivotal predictive biomarkers in determining prognosis and response to immunotherapy in colorectal cancer (CRC) patients. While Whole Exome Sequencing (WES) stands as the gold standard for TMB assessment, carry substantial costs and demand considerable time commitments. Additionally, the heterogeneity among high-TMB patients remains poorly characterized....

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Source

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Identifiers

PMID: 39543663
DOI: 10.1186/s13062-024-00564-0
PMCID: PMC11566893

Genes

DNAH5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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