Article
Predicting colorectal cancer tumor mutational burden from histopathological images and clinical information using multi-modal deep learning.
Bioinformatics (Oxford, England) - 15 Nov 2022
Huang Kaimei, Lin Binghu, Liu Jinyang, Liu Yankun, Li Jingwu, Tian Geng, Yang Jialiang
Abstract excerpt
MOTIVATION: Tumor mutational burden (TMB) is an indicator of the efficacy and prognosis of immune checkpoint therapy in colorectal cancer (CRC). In general, patients with higher TMB values are more likely to benefit from immunotherapy. Though whole-exome sequencing is considered the gold standard for determining TMB, it is difficult to be applied in clinical practice due to its high cost. There are also a few DNA...
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