Article

Continuous Prediction for Tumor Mutation Burden Based on Transcriptional Data in Gastrointestinal Cancers

2022-07-05

Abstract excerpt

<h4>Background: </h4> Tumor mutation burden (TMB) has been considered biomarker for using of immune checkpoint inhibitors(ICIs), but whole exome sequencing(WES) and cancer gene panel(CGP) based on next generation sequencing for TMB detection are costly. Here, we use transcriptome data of TCGA to construct a model for TMB prediction in gastrointestinal tumors. <h4>Methods: </h4> Transcriptome data, somatic mutation...

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Literature Corpus work: 5008ecf5-b9ad-5968-9301-99b436b4e6f1
DOI: 10.21203/rs.3.rs-1708779/v1

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