Multi-Level Analysis and Identification of Tumor Mutational Burden Genes across Cancer Types.

Abstract excerpt

Tumor mutational burden (TMB) is considered a potential biomarker for predicting the response and effect of immune checkpoint inhibitors (ICIs). However, there are still inconsistent standards of gene panels using next-generation sequencing and poor correlation between the TMB genes, immune cell infiltrating, and prognosis. We applied text-mining technology to construct specific TMB-associated gene panels cross...

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• Biomarkers, Tumor
• Colorectal Neoplasms
• High-Throughput Nucleotide Sequencing
• Mutation
• Prognosis