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Article

Histopathological characteristics and artificial intelligence for predicting tumor mutational burden-high colorectal cancer.

Journal of gastroenterology - 1 Jun 2021

Shimada Yoshifumi, Okuda Shujiro, Watanabe Yu, Tajima Yosuke, Nagahashi Masayuki, Ichikawa Hiroshi, Nakano Masato, Sakata Jun, Takii Yasumasa, Kawasaki Takashi, Homma Kei-Ichi, Kamori Tomohiro, Oki Eiji, Ling Yiwei, Takeuchi Shiho, Wakai Toshifumi

Abstract excerpt

BACKGROUND: Tumor mutational burden-high (TMB-H), which is detected with gene panel testing, is a promising biomarker for immune checkpoint inhibitors (ICIs) in colorectal cancer (CRC). However, in clinical practice, not every patient is tested for TMB-H using gene panel testing. We aimed to identify the histopathological characteristics of TMB-H CRC for efficient selection of patients who should undergo gene...

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PMID: 33909150
DOI: 10.1007/s00535-021-01789-w

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