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Article

Optimizing the evaluation of gene-targeted panels for tumor mutational burden estimation.

Scientific reports - 26 Oct 2021

Li Yawei, Luo Yuan

Abstract excerpt

Though whole exome sequencing (WES) is the gold-standard for measuring tumor mutational burden (TMB), the development of gene-targeted panels enables cost-effective TMB estimation. With the growing number of panels in clinical trials, developing a statistical method to effectively evaluate and compare the performance of different panels is necessary. The mainstream method uses R-squared value to measure the...

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Identifiers

PMID: 34702927
DOI: 10.1038/s41598-021-00626-7
PMCID: PMC8548549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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