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Article

Continuous prediction for tumor mutation burden based on transcriptional data in gastrointestinal cancers.

BMC medical informatics and decision making - 18 Dec 2024

Hu Beibei, Yin Guohui, Zhu Jialin, Bai Yi, Sun Xuren

Abstract excerpt

BACKGROUND: Tumor mutation burden (TMB) has been considered a biomarker for utilization of immune checkpoint inhibitors(ICIs), but whole exome sequencing(WES) and cancer gene panel(CGP) based on next generation sequencing for TMB detection are costly. Here, we use transcriptome data of TCGA to construct a model for TMB prediction in gastrointestinal tumors. METHODS: Transcriptome data, somatic mutation data and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39695561
DOI: 10.1186/s12911-024-02794-8
PMCID: PMC11654420

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CD4

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